Ttc9a

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August undefined, 2024

WebSep 14, 2012 · TTC9A was induced by mitogens, estrogen and growth factors in breast cancer cells MCF-7 [2]. TTC9A expression is also significantly higher in breast cancer tissues than the adjacent normal tissues [17]. These indicate that TTC9A expression is positively associated with cell proliferation and the presence of growth-stimulating signals. WebTTC9A deficient mammary gland showed significant increase in mammary ductal elongation and branching on estrogen and progesterone treatment, demonstrating aberration in hormone receptor signaling in absence of TTC9A.These observations suggest that TTC9A negatively regulates mammary gland development and the possibility that …

TTC9A deficiency induces estradiol-mediated changes in …

WebTTC9A through estradiol action in emotional control. Although we know that Ttc9a-/- induces anxiety-like behavior through the effect of estradiol on serotonergic system 9, the possible mechanisms of TTC9A on estradiol and neuroplasticity-related changes remain obscure. In this study, we investigated the effects of TTC9A and estradiol WebSep 6, 2024 · It is plausible therefore that TTC9A negatively regulates ERalpha activity through interacting with co-chaperone proteins such as FKBP38 and FKBP51. TTC9A acts as a chaperone protein to facilitate the function of tropomyosins (including Tm5NM-1) in stabilizing microfilament and it may play a role in cancer cell invasion and metastasis hidraqua english contact

TTC9A deficiency induces estradiol-mediated changes in ... - PubMed

WebNumber of male and female pups from Ttc9A KO mice crosses. There is no 13 significant difference in the male and female offspring ratios from Ttc9a+/+ X Ttc9a+/+, 14 Ttc9a+/-X Ttc9a+/-and Ttc9a-/-X Ttc9a-/- crosses. 15 16 (Table S3) Supplementary Table 3. Organ Weights of female Ttc9a KO mice at 3 weeks 17 and 6 weeks of age 18 WebWe'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2024 ... WebUniProtKB unreviewed (TrEMBL) Organism. Catharus fuscescens (Veery) Amino acids. 181. Protein existence. Predicted. Annotation score. 1/5. how far can a 6x8 beam span

TTC9A deficiency induces estradiol-mediated changes in …

WebApr 1, 2024 · Since Ttc9a is induced by estrogen in estrogen target tissues, these results suggest that Ttc9a is a negative regulator of estrogen function through a negative … WebApr 1, 2024 · In brief, Ttc9a-/-and wildtype female mice were subjected to ovariectomy (OVX) as reported (Lim et al., 2016; Lin et al., 2001). After a 10-day recovery period, mice were … hidrangea pink and roseWebAbstract. Tetratricopeptide repeat domain 9A (TTC9A) is a target gene of estrogen and progesterone.It is over-expressed in breast cancer. However, little is known about the physiological function of TTC9A.The objectives of this study were to establish a Ttc9a knockout mouse model and to study the consequence of Ttc9a gene inactivation. The … hidra schede tecniche

"WebAug 12, 2008 · TTC9A (1–100), which contains the first TPR domain, interacted with Tm5NM-1 to some extent but the interaction was weaker than TTC9A (1–115). Since the first TPR domain lies in residues 57–90, it is plausible that the first TPR domain is required for the interaction. " - Ttc9a

Ttc9a

WebRelative TTC9A mRNA increased by threefold in the uterus (J) on E2B treatment. 36B4 was used as the cDNA input control. Data analyzed by Mann-Whitney non-parametric … WebEmerging evidence suggests that estradiol is a potent modulator of neuroplasticity. As estradiol and neuroplasticity changes are both implicated in mood regulation, and estradiol activity is negatively regulated by TTC9A, we hypothesized that the behavioral changes induced by Ttc9a-/- is also mediated by neuroplasticity-related mechanisms.

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Web15 rows · Mar 21, 2024 · GeneCards Summary for TTC9 Gene. TTC9 (Tetratricopeptide Repeat Domain 9) is a Protein Coding gene. Diseases associated with TTC9 include Large … WebThe involvement of tetratricopeptide repeat domain 9A (TTC9A) deficiency in anxiety-like responses and behavioral despair through estradiol action on the serotonergic system has been reported. Emerging evidence suggests that estradiol is a potent modulator of neuroplasticity. As estradiol and neurop …

WebDC Field Value Language; dc.contributor.author: Lim, Lee Wei: en: dc.contributor.author: Shrestha, Smeeta: en: dc.contributor.author: Or, Yu Zuan: en: dc.contributor ... WebSep 6, 2024 · It is plausible therefore that TTC9A negatively regulates ERalpha activity through interacting with co-chaperone proteins such as FKBP38 and FKBP51. TTC9A acts …

WebPrimePCR™ Template for Probe Assay: TTC9, Human Reaction: 200 x 20 µl reactions Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay. Webstudies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen. In this study we investigated the role of TTC9A on …

WebApr 1, 2024 · In brief, Ttc9a-/-and wildtype female mice were subjected to ovariectomy (OVX) as reported (Lim et al., 2016; Lin et al., 2001). After a 10-day recovery period, mice were administered a subcutaneous injection of either 10 μg/kg 17-β-estradiol benzoate . Effects of Ttc9a-/-and estradiol modulation on tail suspension immobility

WebThe involvement of tetratricopeptide repeat domain 9A (TTC9A) deficiency in anxiety-like responses and behavioral despair through estradiol action on the serotonergic system … hidraplex 27 9g hidrante em inglesWebAnti-TTC9 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution; Synonyms: Anti … hidrant pompa performans testiWebNov 21, 2016 · Tetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have … hidraplex cocoWebApr 1, 2024 · We aimed to investigate the interactive roles of TTC9A and estradiol modulation on behavioral neuroplasticity. The tail suspension immobility data and brain … hidrartrosis facetariaWebSep 14, 2012 · 1. Introduction. Tetratricopeptide repeat domain 9A (TTC9A) is a member of TTC9 family proteins that also include TTC9B and TTC9C. Human TTC9A gene was first identified by sequence analysis of a cDNA clone from a brain cDNA library .It was confirmed to code for a 222 amino acid TTC9A protein in human using mouse polyclonal antibody … how far can a 747 flyWebTTC9A to be 222 aa. Using mouse polyclonal antibody generated against TTC9A protein, TTC9A was shown to be ubiquitously expressed in human tissues. In breast cancer cells, TTC9A was predominantly concentrated to the endoplasmic reticulum and was regulated by a number of factors, such as growth factors, serum factors and steroid hormones [2]. hidrant hattı