WebSep 1, 2024 · As the downstream of RTKs, SOS Ras/Rac guanine nucleotide exchange factor 1 (SOS1) and protein tyrosine phosphatase non-receptor type 11 (PTPN11, best known as SHP2) promote the ratio of GDP-GTP... WebMar 11, 2024 · IACS-13909 is a specific and potent allosteric inhibitor of SHP2. Moreover, IACS-13909 potently impedes the proliferation of tumors harboring a broad spectrum of activated receptor tyrosine kinases as the oncogenic driver. IACS-13909 potently suppresses the phosphatase activity of purified full-length, recombinant human SHP2 protein with an …
Shipping Out MEK Inhibitor Resistance with SHP2 Inhibitors
WebRecently, Wang et al reported that dioscin overcomes TKI resistance in epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma cells by reducing the expression of SHP2 and its interaction with GAB1. 2 Additionally, Chen et al found a selective oral SHP2 allosteric inhibitor (SHP099) and demonstrated its ability to inhibit ERK ... WebJul 3, 2024 · Here, we report that SHP2 expression was much higher in PC9GR cells than PC9 cells, and malignant LUAD cells contained higher SHP2 than BEAS-2B pulmonary … dictionary\u0027s 95
Morvarid (Mori) Mohseni, Ph.D - Director, Oncology Drug Discovery …
WebApr 13, 2024 · Neuron-specific deletion of the SHP2 results in obesity and leptin resistance in mice, suggesting that the SHP2 pathway is also important in mediating leptin’s anti-obesity action . Phospho-Tyr985 also binds to the SH2 domain of SOCS3, and SOCS3 in turn inhibits the activation of the LepRb/JAK2 pathways [ 39 ]. WebFeb 23, 2024 · The tyrosine phosphatase Shp2 is associated with tumorigenesis in small cell lung cancer (SCLC). However, the relationship between Shp2 and resistance to chemotherapy remains unclear. WebDec 1, 2000 · Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition 30 October 2024 Jonathan R. LaRochelle, … city duty free melbourne