Immunophilin family
In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases (PPI) that catalyze the interconversion between the cis and trans isomers of peptide bonds containing the amino acid proline (Pro). They are chaperone molecules that generally assist in the proper folding of diverse "client" proteins. Immunophilins are traditionally classified into two families that differ in sequence and biochemical characteristics. These two families are: "cyclosporin-binding cyclophil… WitrynaCurrent data suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby …
Immunophilin family
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Witryna1 gru 2024 · This study systematically analyzed members of the apple cyclophilin family and confirmed the involvement of MdCYP16 as a nuclear-localized MD CYP that acts … Witryna21 paź 2008 · The Arabidopsis immunophilin family consists of 29 cyclophilin and 22 FKBP isoforms distributed in various cellular locations ().Perhaps most striking is the …
WitrynaThis review focuses on molecular characteristics of the canonical and non-canonical immunophilin family members from human and Plasmodium falciparum and P. … WitrynaFK506-binding proteins (FKBP) belong to the immunophilin family and are best known for their ability to enable the immunosuppressive properties of FK506 and rapamycin. For rapamycin, this is achieved by inducing inhibitory ternary complexes with the kinase mTOR. The essential accessory protein for this gain-of-function was thought to be …
WitrynaThe protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein … Witryna2 paź 2007 · In Arabidopsis, genes encoding 52 putative immunophilins have been identified: 23 FKBPs and 29 CYPs ().This group is by far the largest immunophilin …
WitrynaEncodes a member of the FKBP-type immunophilin family that functions as a histone chaparone. Binds to 18S rDNA and represses its expression. FKBP53 FK506 …
Witryna15 cze 2012 · This protein family has been shown to be overexpressed in certain cancers and cancer cell lines. Grb7 and a receptor tyrosine kinase (RTK), erbB2, are … increase savings rateWitrynaAbstract. Immunophilins are chaperones that may also exhibit peptidylprolyl isomerase (PPIase) activity. This review summarizes our knowledge of the two largest families of … increase samsung monitor brightnessWitrynaNicholas J Turner. Cyclophilin A (CypA) is a member of the immunophilin family of proteins and receptor for the immunosuppressant drug cyclosporin A (CsA). Here we describe the design and ... increase scoresWitryna8 sty 2008 · Immunophilin ligands, such as FK506, cyclosporin A, rapamycin, 3-normeridamycin, V-10,367, and GPI-1046, have been shown to have neuroprotective activities (1–4).Immunophilins comprise the family of FK506-binding proteins (FKBPs) having peptidyl-prolyl cis-trans isomerase (PPIase) activities and were proposed as … increase satietyWitryna31 paź 2013 · Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, … increase scope meaningWitrynaThis review focuses on molecular characteristics of the canonical and non-canonical immunophilin family members from human and Plasmodium falciparum and P. … increase scan speed brother scannerWitrynaEach immunophilin family has been structurally characterised with a variety of small molecule ligands, principally immunosuppressive drugs and their analogues and an … increase screen lighting