WebUnder normoxia, HIF has a low transcriptional activity. In addition, HIF has been reported to be upregulated in certain pathological conditions such as cancer where a high expression of HIF correlates with a poor prognosis. The aim of this project is to understand the molecular mechanisms by which human HSC response to their hypoxic environment. Web3 de set. de 2010 · Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM). In this study, we show that normal HSCs maintain …
HIF-1 and its antagonist Cited2 Regulators of HSC quiescence
Web3 de set. de 2024 · HIF-prolyl hydroxylase (HIF- PH) is the primary enzyme for degrading HIF, resulting in inhibition or slowing of erythropoiesis. Therefore, HIF-PH inhibitors/HIF stabilizers can be used to treat anemia. HIF-PH inhibitors (HIF-PHI), also known as hypoxia-inducible factor stabilizers (HIF-stabilizers), are designed to inhibit enzymatic degradation ... WebHIF-1α expression levels in HSC increase with fibrosis as shown in the Mdr2-/- mice receiving no cholesterol supplementation. Previous studies reported similar findings [ 57 ] and attributed a critical role in collagen deposition to HIF-1 α . hierarchy domain
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Web3 de set. de 2010 · Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM). In this study, we show that normal HSCs maintain … Web24 de mai. de 2024 · In addition, HIF-1α is transcriptionally induced by Meis1, a transcription factor essential for HSC stemness . Metabolome and flux analysis suggests that HSCs consume less oxygen and activate of glycolysis to a greater extent than their differentiated counterparts [ 10 ], an observation partly explained by relatively higher, HIF-1α … Web30 de jul. de 2024 · Under normoxia, HIF-1α is hydroxylated by prolyl-4-hydroxylase (PHD) and factor inhibiting HIF-1 (FIH), and interacts with von Hippel-Lindau (VHL), resulting in … hierarchy diagram word