Web3 de abr. de 2024 · This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy … Web9 de abr. de 2024 · To answer to these questions, we treated epithelial HaCaT and breast cancer MCF-7 cells with different ZnO-NR concentrations. Our results showed that ZnO-NR treatments increased cell death through ROS accumulation, HIF-1α and endothelial PAS domain protein 1 (EPAS1) activation, and induction of autophagy and mitophagy in both …
Frontiers Non-Canonical Mechanisms Regulating Hypoxia …
WebThe figure illustrates the peak distribution of HIF-2-alpha binding within a 250 Kb region of chromosome 11 as detected using anti-HIF-2-alpha antibody ab243861. ChIP-seq validation performed by Active Motif, Carlsbad, CA. Immunocytochemistry/ Immunofluorescence - Anti-HIF-2-alpha antibody [BL-95-1A2] (ab243861) Web12 de set. de 2024 · HIF-1α is involved in the regulation of TRIM28 on DLL, Notch and VEGFR expression. ... 44 Other studies have reported that phosphorylation of TRIM28 Ser473 can also be induced by metabolic stresses through ROS and p38, both of which play important roles in VEGF-induced angiogenesis. great short vacation getaways
Hypoxia-mediated cancer stem cell resistance and targeted therapy
Web12 de mar. de 2024 · HIF-1α mediates ROS production by mitochondria and the Nox family and regulates the redox ... Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem. 2009; 284:16767–16775. doi: 10.1074/jbc.M901790200. [PMC … WebWe offer HIF-2 alpha/EPAS1 antibodies that have been cited in 775+ publications with 35+ customer reviews. Browse our extensive catalog for anti-HIF-2 alpha polyclonal … WebThe hypoxia inducible factor (HIF) prolyl hydroxylases (PHD1-3) play a central role in cellular responses to hypoxia in humans and other animals. 1,2 PHD-catalysed prolyl hydroxylation of HIF-α isoforms (Pro402, Pro564 in human HIF-1α) signals for proteasomal degradation, hence hindering formation of transcriptionally active α,β-HIF. When oxygen levels are … floral shop republic mo