WebApr 30, 2024 · An unexpected radical detosylation during the synthesis of dapholdhamine B further inspired an ambitious radical cyclization cascade strategy, which eventually led to an efficient total synthesis ... Webhimalensine A, daphnezomine A-type alkaloid dapholdhamine B, bukittinggine-type alkaloid caldaphnidine O, and yuzurimine-type alkaloid caldaphnidine J (Figure 1).[4b, 18] Particularly, the calyciphylline A-type subfamily has triggered enormous synthetic activities.[4a, 19] From 2013 to 2024, the Li group accomplished remarkable total
Total Synthesis of Daphniphyllum Alkaloids: From Bicycles to ...
WebLian-Dong Guo, Jieping Hou, Wentong Tu, Yan Zhang, Yue Zhang, Louxi Chen, Jing Xu. Total Synthesis of Dapholdhamine B and Dapholdhamine B Lactone. Journal of the … WebMay 29, 2024 · Total Synthesis of Dapholdhamine B and Dapholdhamine B Lactone. Journal of the American Chemical Society 2024, 141 (29) , 11713-11720. DOI: … netscaler gateway - ny 800-flowers.net
Dapholdhamines A−D, Alkaloids from Daphniphyllum …
WebDapholdhamine B ( 27 ), isolated from D. oldhami by Hao and co-workers, 51 is a Daphnezomine A-type Daphniphyllum alkaloid. These compounds typically contain an aza-adamantane skeleton including eight contiguous stereocenters. WebJun 30, 2024 · Recently, our group has accomplished the first total synthesis of dapholdhamine B. Based on these results, we have also explored the approach towards the total synthesis of its natural analogs, daphnezomine A and B. Key steps of our work include Huang’s amide-activation−annulation and a Hutchins-Kabalka reductive … WebNov 17, 2024 · We then introduce the synthesis of daphnezomine A-type alkaloid dapholdhamine B, which possesses a unique aza-adamantane core. This target molecule was fabricated using key reactions including Huang's amide-activation-annulation. netscaler gateway pinnaclehealth.org