Cytosolic nucleic acid-sensing pathways

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August undefined, 2024

WebThe host cell signaling pathways that lead to caspase-1 activation in macrophages infected with three bacterial pathogens that replicate in the host cell cytosol-the gram-positive … WebJan 1, 2024 · In general, nucleic acid sensing by multiple PRRs can trigger activation of type I IFNs, inflammasome, and other inflammatory signaling pathways. As seen with many other receptors, dysregulation in the recognition of nucleic acids can promote the pathogenesis of autoimmune and inflammatory diseases such as arthritis, lupus, colitis, etc.

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WebThe host cell signaling pathways that lead to caspase-1 activation in macrophages infected with three bacterial pathogens that replicate in the host cell cytosol-the gram-positive bacterium L. monocytogenes and the gram-negative bacteria S. flexneri and F. tularensis-have been studied so far. The various responses triggered after engagement of ... WebThe IL-6 pathway and early STAT3 signalling are enhanced in the absence of cytosolic nucleic acid sensing. (A) Systemic levels of IL-6 were measured using serum samples from 4 to 7... shane\u0027s seafood \u0026 barbq bossier city la

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WebApr 14, 2024 · The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take … WebDetection of endogenous nucleic acids by cytosolic receptors, dependent on STING, and endosomal sensors, dependent on Unc93b1, can provoke inflammatory responses that contribute to a variety of ... WebJul 15, 2024 · Using a series of mammalian knockout cell lines, we demonstrate that, surprisingly, both the cGAS/STING-dependent DNA-sensing pathway and the MAVS … shane\\u0027s sheepies

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Animal Models for the Study of Nucleic Acid Immunity: Novel …

WebApr 14, 2024 · The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take advantage of its development by sensing different ionic concentrations in the external milieu. This pathway involves the activation of phospholipase C and an increase in … WebIn mammalian cells, two paradigmatic cytosolic NA-sensing pathways are the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon … shane\u0027s seafood \u0026 bbq bossier cityWebSep 9, 2024 · Intracellular innate immunity and mechanism of action of cytosolic nucleic acid receptor-mediated type I IFN against viruses. ... a lethal RIG-I-dependent interferon response. 44 All these cases suggest that activation as well as inactivation of the cytosolic nucleic acid sensing pathway are important in providing a proper response … shane\u0027s seafood \u0026 bbq bossier city la

"WebOct 24, 2024 · Pattern recognition receptors such as nucleotide-binding oligomerization domain (NOD)-containing protein receptors (NLRs) and the pyrin and hematopoitic interferon-inducible nuclear protein (HIN) domain (PYHIN) receptors initiate the inflammatory response following cell stress or pathogenic challenge. When activated, some of these … " - Cytosolic nucleic acid-sensing pathways

Cytosolic nucleic acid-sensing pathways

The IL-6 pathway and early STAT3 signalling are enhanced

WebApr 1, 2024 · cGAS and AIM2 are CDSs that are activated in the presence of cytosolic dsDNA and are expressed in various cell types, including immune and tumor cells. The recognition of tumor-derived dsDNA by CDSs in the cytosol of tumor-infiltrating dendritic cells (TIDCs) activates the innate and acquired immunity, thereby enhancing anti-tumor … WebApr 29, 2024 · The cytosolic DNA-sensing cGAS-STING pathway in innate immunity. Cyclic GMP-AMP synthase (cGAS) is a protein, which detects various cytosolic dsDNA, including viral DNA, damaged self-DNA released by dying cells, micronuclei, and mitochondrial origins. dsDNA activates cGAS viaforming cGAS-dsDNA in 2:2 complexes.

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WebSep 20, 2024 · cGAS is a kind of cytosolic DNA sensor which initiates innate immune (Fig. 1 ). Notably, cGAS and its downstream regulators form a major DNA-sensing mechanism, sensing foreign and self-DNA in the cytoplasm and sometimes in the micronucleus and nuclei as well [ 8 ]. WebNov 26, 2024 · Type I interferonopathies are caused by disturbances in intracellular nucleic acid metabolism or in cytosolic nucleic acid sensing pathways that induce an overproduction of type I IFNs, triggering autoimmunity . Cytosolic nucleic acid sensors such as cyclic GMP–AMP synthase and MDA5 recognize broken intracellular self-DNA …

WebSep 9, 2024 · Cytosolic nucleic acid detection pathways have been vastly explored in vitro (in immune and nonimmune cell types) and in vivo, mostly focusing on murine models. However, recent work underscores the existence of cell-type-dependent and species-specific detection mechanisms, urging for re-evaluation of nucleic acid sensing in … WebCytosolic receptors sense viral and intracellular bacterial genomes, as well as nucleic acids produced during replication. Once activated, these sensors trigger multiple signaling cascades, converging on the …

WebMicrobial nucleic acids are major signatures of invading pathogens, and their recognition by various host pattern recognition receptors (PRRs) represents the first step toward an efficient innate immune response to clear the pathogens. The nucleic acid–sensing PRRs are localized at the plasma membrane, the cytosol, and/or various cellular organelles. … WebMay 28, 2024 · Abstract 3000 Background: Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy in oncology. PARP7 is a member of the monoPARP class of enzymes and a newly identified negative regulator of nucleic acid sensing in tumor cells.

WebBiological pathway information for Cytosolic DNA-sensing pathway from WikiPathways.

WebThe infected cDC2 senses the replicating virus via its cytosolic nucleic acid receptors and secretes proinflammatory cytokines and type I IFNs, but its innate responses and capacity to present viral antigens are limited by viral interference with innate response pathways and by the cytopathic effect of the virus. shane\u0027s seafood youree menuWebNational Center for Biotechnology Information shane\u0027s seafood \u0026 bbq shreveport la shane\\u0027s shine shop princeton ilWebApr 9, 2024 · Cytosolic receptors mediate recognition of danger damage-associated molecular patterns (DAMPs) signals. Once activated, these sensors trigger multiple … shane\u0027s skeet shoot north carolinaWebRecent discoveries of cytosolic innate immune sensing pathways, including sensing of cytosolic DNA involving the adaptor protein stimulator of interferon genes (STING, also termed MYPS, MITA, ERIS) or cytosolic RNA via the adaptor MAVS have greatly advanced our understanding of immunity. shane\u0027s shreveport youreeWebMar 27, 2024 · Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade Qian Zhang, Fansen Meng, Shasha Chen, Steven W. Plouffe, Shiying Wu, Shengduo Liu, Xinran Li,... shane\\u0027s spidersWebNov 2, 2024 · Cytosolic DNA can be recognized by cyclic GMP-AMP (cGAMP) synthase (cGAS), which in turn activates stimulator of IFN genes (STING). Signal transduction from these sensors converges to activate... shane\u0027s signs