Cpg odn 1585
WebProduct information "ODN 1585 (Type A) Endotoxin-free (sterile)" 3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in … WebMar 15, 2004 · In contrast, CpG-A (ODN 1585; ODN 2216) was unable to enhance the frequency of Melan A 26-35 A27L–specific CD8 + T cells (from 1.1% HLA-A2/Melan A 26 …
Cpg odn 1585
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WebODN 1585 is a Class A CpG ODN specific for mouse TLR9. Class A CpG ODNs are characterized by a central, phosphodiester, CpG-containing palindromic motif and a 3’ … CpG ODN 1585 is a synthetic immunostimulatory oligonucleotide … Type C CpG ODNs combine features of both types A and B. They contain a … Screening Specifications. Short turnaround time - Screening turnaround: ONLY 3 … Toll-Like Receptors (TLR) recognize specific pathogen-associated molecular … As expected, mTLR9 overexpression in HEK-Blue™ mTLR9 cells allows potent … InvivoGen offers high-quality CpG ODNs that are cell-culture tested and … Custom Services InvivoGen provides two custom services: Immunomodulatory … Cloning & Expression Vectors. InvivoGen provides a broad range of cloning and … NLRP1 & NLRP3: a tale of two inflammasome sensors . In this first … WebNov 1, 2001 · The therapeutic effects of CpG 1585 in melanoma required the presence of NK but not T or B cells and were not associated with the induction of a tumor-specific …
WebODN 1585 is a type A CpG ODN that specific for murine TLR9. Features • Classification: Type A • Product format: Lyophilized product • Sequence: 5'-ggGGTCAACGTTGAgggggg-3' (lower case letters are phosphorothioate) • Specificity: Mouse, Rat. Storage. Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at ... WebNov 1, 2001 · In particular, a distinct type of CpG motif, which has a chimeric backbone in combination with poly(G) tails, is a potent inducer of NK lytic activity but has little effect on cytokine secretion or B cell proliferation. One such NK-optimized CpG ODN (1585) can induce regression of established melanomas in mice.
WebDifferent types of CpG ODNs were identified based on their differing biological effects on different cell types: ODN Type A is a potent inducer of IFN-alpha in human PDC, (i.e. ODN 1585 or 2216) leading to antigen presenting cell (APC) maturation, whereas ODN Type B (i.e. ODN 2006 or ODN 1668 / ODN 1826) is a weak inducer of IFN-alpha but rather … WebCpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules containing unmethylated CpG motifs derived from bacterial DNA. CpG ODNs …
WebCpG-containing oligodeoxynucleotides (CpG ODN) can also induce, in adult mice, potent Th1-like humoral and cell-mediated immune responses against a variety of antigens (29, 35–39), and these effects synergize with those of alum (35). In the present study we evaluate CpG ODN, alone or with alum, to induce immune responses against the …
WebCpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G"). The "p" refers to the phosphodiester link between consecutive nucleotides, although some ODN have a modified phosphorothioate (PS) … pilote canon mp550 windows 11WebCpG ODN 1826 might be a promising therapy on diabetic cardiac autonomic neuropathy. CpG ODN, as a TLR9 agonist, activates the TLR9 signaling pathway by mimicking the … pilote canon mp610 windows 10WebJan 8, 2024 · In this study, we have used CpG-ODN 1585, which belongs to type-A CpG-ODNs, which stimulate and activate T cells through engaging TLR9 expressed on the pDC cells. CpG-ODN is being explored clinically for use as a vaccine adjuvant in combination with ICIs, chemo, or radiotherapy for various cancer types ... pilote canon mx470 series printer ws