Cisplatin topotecan cervical cancer

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August undefined, 2024

WebJun 3, 2013 · Major Finding: Median overall survival was 17.0 months with bevacizumab plus chemotherapy vs. 13.3 months with chemotherapy alone (P = .0035).Data Source: A randomized phase III trial (GOG 240) among 452 women with recurrent, persistent, or metastatic cervical cancer.Disclosures: Dr. WebCisplatin is called the “penicillin of cancer” because it is used so widely and it was the first big chemotherapy drug. Cisplatin also plays an interesting role in the history of …

Cervical Invasive – Treatment of recurrent cancer

WebGeneral. DRG Category: 740. Mean LOS: 3.9 days. Description SURGICAL Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy With Complication or Comorbidity. DRG Category: 755. Mean LOS: 4.1 days. Description MEDICAL Malignancy, Female Reproductive System With Complication or Comorbidity. There's more to see -- … WebJan 27, 2024 · Many different chemotherapy drugs are used to treat recurrent cervical cancer, including cisplatin, carboplatin, ifosfamide, irinotecan, gemcitabine, paclitaxel, topotecan, and vinorelbine. These drugs may be given alone or in combination. Giving chemotherapy given at the same time as radiation therapy helps the radiation therapy … iphonese3 買取

Chemotherapy for recurrent cervical cancer - PubMed

WebMar 1, 2004 · SAN DIEGO-For the first time, a combination regimen has shown improved survival over single-agent cisplatin (Platinol) for the treatment of advanced cervical … WebSingle-agent cisplatin remains the current standard therapy for advanced, persistent or recurrent cervical cancer. Several single-agents have been tested, but none has been found to be superior compared to cisplatin. Both topotecan and paclitaxel in combination with cisplatin, have yielded superior … Chemotherapy for recurrent cervical cancer WebJul 26, 2024 · Chemotherapy consisted of cisplatin at a dose of 50 mg per square meter of body-surface area, plus paclitaxel at a dose of 135 or 175 mg per square meter or topotecan at a dose of 0.75 mg per... orangeburg sc times and democrat newspaper

A phase II study of ifosfamide and cisplatin chemotherapy for ...

WebMar 1, 2004 · SAN DIEGO For the first time, a combination regimen has shown improved survival over single-agent cisplatin (Platinol) for the treatment of advanced cervical cancer, according to the Gynecologic Oncology Group (GOG) protocol 179, which was presented at the 35th Annual Meeting of the Society of Gynecologic Oncologists … WebThe cisplatin-topotecan arm had the greatest rates of myelotoxicity (grade 3 or more: anemia in 34.9%, neutropenia in 82.6%, and thrombocytopenia in 34.9%), while cisplatin-paclitaxel had greater rates of alopecia (grade 2, 54%). The other toxicities were similar for all treatment arms. iphonese3 重启WebJan 16, 2024 · Topotecan is indicated for the treatment of patients with metastatic carcinoma of the ovary after failure of first-line or subsequent therapy. Hycamtin capsules are indicated as monotherapy for the treatment of adult patients with relapsed small cell lung cancer (SCLC) for whom re-treatment with the first-line regimen is not considered … iphonese3 評価

"WebThis review focuses on the mechanism of action and toxicities of topotecan, as well as its role as a radio-sensitizer and chemotherapeutic agent in the management of advanced, recurrent, or persistent cervical cancer. Other combination modalities and dosages are also discussed. Keywords: topotecan, combination chemotherapy, advanced cervical ... " - Cisplatin topotecan cervical cancer

Cisplatin topotecan cervical cancer

Topotecan, Cisplatin and Bevacizumab for Recurrent/Persistent …

WebOct 1, 2006 · On June 14, 2006, the FDA approved topotecan for use in combination with cisplatin for the treatment of women with stage IVB, recurrent or persistent …

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WebSep 21, 2016 · On the basis of reported activity of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) or topotecan plus cisplatin in advanced cervix cancer, we … WebIntroduction. Small-cell lung cancer (SCLC) accounts for about 15% to 17% of all diagnosed lung cancers. Nevertheless, due to its aggressive and rapid behavior, SCLC is the leading cause of death among all malignancies. 1 Promising progress in the field of non-small cell cancer (NSCLC) regarding targeted therapy and immunotherapy has been achieved in …

WebMay 4, 2024 · There is no standard chemotherapy regimen for NECC, but cisplatin/carboplatin and etoposide (EP) was the most commonly used treatment scheme (24/40 studies). Overall, the prognosis of women with NECC was poor with a mean recurrence-free survival of 16 months and a mean overall survival of 40 months. WebThis review focuses on the mechanism of action and toxicities of topotecan, as well as its role as a radio-sensitizer and chemotherapeutic agent in the management of advanced, …

WebFeb 20, 2014 · Chemotherapy consisted of cisplatin at a dose of 50 mg per square meter of body-surface area, plus paclitaxel at a dose of 135 or 175 mg per square meter or topotecan at a dose of 0.75 mg per square meter on days 1 to 3, plus paclitaxel at a dose of 175 mg per square meter on day 1. WebA total of 44 women received a combination of ifosfamide (1.5 g/m2 daily x5) and cisplatin (50 mg/m2 on day 1 only) as first-line chemotherapy for recurrent or metastatic carcinoma of the cervix. In all, 12/42 (38%) evaluable patients responded, with the median duration of response being 7 months. Bone marrow and gastrointestinal toxicity were frequently …

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.

WebWhat is cisplatin and topotecan? Cisplatin and topotecan is used to treat advanced cervical cancer. It is best to read this information with our general information about … iphonese364wWebOct 22, 2024 · The chemo drugs most often used to treat cervical cancer that has come back or spread to other areas include: Cisplatin Carboplatin Paclitaxel (Taxol) … orangeburg sc st paul churchWebRecent data suggest that topotecan, when used concurrently with cisplatin, may be the new standard of care for the management of recurrent or advanced cervical cancer. Ongoing phase III studies (GOG-204, AGO-Zervix-1) will compare this combination with other cisplatin-containing and cisplatin-free combinations. iphonese3a15残血版WebSeven phase I–III clinical trials using topotecan, both as a single agent and in combination with cisplatin or paclitaxel, in patients with recurrent or advanced carcinoma of the cervix were reviewed. Data from two studies in which topotecan was used in combination with radiotherapy for induction therapy were also evaluated. iphonese3 重さWebThe trial enrolled 617 patients with persistent, recurrent, or first-line metastatic cervical cancer who had not been treated with chemotherapy. Patients were enrolled irrespective … orangeburg sc to daytona beach flWebCisplatin is platinum-based drug as carboplatin, which is used for the treatment of ovarian cancer, particularly cisplatin alone or in combination with gemcitabine as a treatment … orangeburg sc to lugoff scWebFeb 2, 2014 · Topotecan– paclitaxel did not outperform cisplatin–paclitaxel, even among patients with prior exposure to cisplatin. Tumor neovascularization is associated with an aggressive course in cervical cancer. orangeburg sc to dallas tx