WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, … WebAug 15, 2024 · CIS/TRANS isomers have different biological properties. Cis-platin has clinical importance in the treatment of ovarian and testicular cancers. The biological mechanism of the drug's action was long suspected to involve binding of the platinum by …
Molecules Free Full-Text The Challenging Treatment of Cisplatin ...
WebCisplatin is used as an anti-cancer drug because it can bind to the DNA of rapidly growing cells and prevent replication. The trans form of this chemical is not as effective at binding to the DNA. Fac and Mer Stereoisomers When three identical ligands occupy one face of an octahedron, the isomer is said to be facial, or fac. WebIn comparison with cisplatin, they show comparable cytotoxic potency against cisplatin-sensitive human cancer cell lines, cis-[Pt(2-abt)(2)Cl(2)]·H(2)O performing substantially higher activity against cisplatin-resistant cell lines. ... Isomerism Male Molecular Structure Organoplatinum Compounds / chemical synthesis ... port men in sheds
Fundamental studies with cisplatin - PubMed
WebSep 8, 2024 · Cisplatin has a platinum transition metal in the center, connected to two chlorines and two ammonias. It forms a unique complex shape: a square planar complex. Most transition metals with... WebMay 15, 1985 · Cisplatin / therapeutic use* Combined Modality Therapy Culture Techniques DNA / metabolism Dogs Drug Administration Schedule Drug Resistance Humans Isomerism Mice Mutagens Neoplasms / drug therapy* Rats Tissue Distribution Substances Carcinogens Mutagens DNA Cisplatin WebCisplatin (cis-diamminedichloroplatinum(II)) is one of the most commonly used anticancer agents. It is administered intravenously, and on its way into the cell it can interact with blood proteins1and other macromolecules. iron and oak 22 ton log splitter