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Cisplatin-induced apoptosis

WebMoreover, DSF sensitized ovarian cancer cells to cisplatin treatment and enhanced cisplatin-induced apoptosis, both in SDC and MDC. In the present studies, we have used a quantitative method to determine synergism or antagonism of DSF in chemotherapy drug treatment. Three pairs of two-drug combinations and a three-drug combination were … WebSilencing STING by siRNA rescued HaCaT cells from UVB or cisplatin-induced apoptosis. NF-κB, one of the major downstream components of STING pathway, which usually regulates the classical STING apoptotic pathway, was translocated to nucleus in the HaCaT cells irradiated with UVB. This translocation was attenuated by STING silencing.

Cisplatin-induced apoptosis proceeds by caspase-3 ... - PubMed

WebThe chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its executing mechanisms of action are versatile and elusive. Here, we show that cisplatin induces renal tubular cell apoptosis and ferroptosis by … WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected … magnifican https://mrhaccounts.com

Cisplatin-induced apoptosis in auditory cells: role of death recep…

WebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for … WebNov 3, 2024 · Purpose The nephrotoxicity caused by cisplatin severely limits the application and affects related platinum-based therapeutics. Neferine is a dibenzylisoquinoline alkaloid extracted from a Chinese … WebThis study investigated non-targeted metabolomic analysis on ABs and medium from apoptotic HK-2 cells induced with cisplatin or exposure to UV light. ... We did not mean that these differences will result in differences in the extension of apoptosis induced by ABs because we knew from our previous work published in Biochimica et Biophysica … magnifica evo vs lattego

Acute apoptosis by cisplatin requires induction of reactive …

Category:Cisplatin-induced apoptosis in BUMPT cells. (A) BUMPT …

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Cisplatin-induced apoptosis

Cells Free Full-Text Cisplatin-Induced Ototoxicity in …

WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin … WebMay 1, 2008 · Cisplatin activates both intrinsic mitochondrial pathway (blue) and extrinsic death receptor pathway (green) of apoptosis. In addition, ER stress may also be induced (gray). Activation of these pathways leads to caspase-dependent or …

Cisplatin-induced apoptosis

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WebFor example, cisplatin induces apoptosis via ROS overgeneration in osteosarcoma MG-63 cell line , methotrexate triggers cell death by upregulating ROS production in osteosarcoma U-2 OS cells , and carvacrol triggers ROS-dependent apoptosis to suppress proliferation in prostate cancer and lung adenocarcinoma cell lines . WebSep 1, 2024 · Cisplatin is globally used for the treatment of human malignancies. Despite its efficacy, cisplatin use is associated with severe side effects, such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity (cisplatin-induced nephrotoxicity; CIN).

WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer …

WebJan 18, 2016 · Cisplatin induces apoptosis in renal tubular cells Previous studies have suggested that cisplatin might induce apoptosis in renal tubular epithelial cells 8. In our study, NRK-52E cells... WebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs highlights the complexity of cisplatin resistance mechanisms even within one tumour entity, explaining heterogeneity in patient responses to chemotherapy.

WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the …

WebRenal tubular epithelial cell apoptosis is the main mechanism of cisplatin-induced acute kidney injury. The role of microRNAs (miRNAs) in the apoptosis of renal tubular epithelial cells has... magnifica esam 03.110.sWebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … cprofile tottimeWebDec 8, 2024 · We observed that combined treatment with mdivi-1 and cisplatin induced downregulation of c-FLIP expression (Figure 2 C). c-FLIP is a major anti-apoptotic protein and is involved in death receptor-mediated apoptosis and chemotherapeutic drug resistance in cancer cells . To investigate the role of c-FLIP downregulation in combined … magnifi cars florange