WebMay 19, 2011 · I'm supposed to increase my dose of Topamax by 25mg every 7 days. I have been on 50mg for 10 days now and the side effects haven't been too unpleasant (knock on wood), so I think I'm ready to increase to 75mg per day. However, my sleep schedule tends to be a bit erratic, and I'm not going to take 75mg "all at once before bed." WebHow to take topiramate. Timing: You can take topiramate with or after food. Take topiramate at the same times each day. If you are taking it twice a day, take your doses in the morning and night. If you are taking it once a day, then it's best taken at bedtime. Swallow your tablets or capsules whole with a full glass of water, milk or juice.
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